The Susten Pass links the Reuss Valley at the foot of the Gotthard Mountain with the Hasli Valley in the Bernese Oberland, and the village of Wassen in Canton Uri with Innertkirchen in Canton Bern. The Susten Pass road was only opened in 1945 and is the first pass road to be purpose-built for vehicular traffic.
Simplon connects Brig in Valais with Domodossola in northern Italy. The Simplon region offers hikers a fantastic mountain panorama and an impressive Alpine flora. The hospice is still led today by the monks of St. Bernhard.