The Segesser brothers Xaver and Josef Plazidus built the Hotel Schweizerhof in 1844/5, a building with fifteen axes. Eduard Segesser then added another wing in 1855/6, based on the original plans of Josef Plazidus Segesser.

Then, in 1861, the hotel became the property of the Family Hauser. Under their reign, in 1863-65, the architect Leonhard Zeugherr added the middle tract, the kitchen, and a hall, which includes the winter garden. In 1868/9 the main building received a face-lift and the adjoining buildings were joined to it by way of passages, all of this under the supervision of Adolf Brunner. From 1885 till 1905, the owner's son-in-law, architect Arnold Bringolf-Hauser, built the small ballroom (parallel to the already existing Zeugheer Hall), the connecting hallway, the Restaurant Galerie and the neo-baroque gabled roof.

1995-2000 the current owners restored the façade, the public rooms, rebuilt the kitchen east of the ballrooms under the supervision of the architectural company Diener & Diener of Basel.

The hotel has received special mention for "the retaining and restoring of the original public rooms dating back to the late 19th, early 20th century, as well as the high-quality standards of the overall overhaul of the traditional Hotel Schweizerhof in Luzern."